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Creators/Authors contains: "Kim, Junhyong"

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  1. ; ; ; ; ; ; ; (, Science)
    The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous cells. The conserved invariant embryonic lineage ofCaenorhabditis elegansandC. briggsaemakes them ideal for comparing cell type gene expression across evolution. Measuring the spatiotemporal divergence of gene expression across embryogenesis, we find a high level of similarity in gene expression programs between species despite tens of millions of years of evolutionary divergence. Nonetheless, thousands of genes show divergence in their cell type specific expression patterns, with enrichment for functions in environmental response and behavior. Neuronal cell types show higher divergence than others such as the intestine and germline. This work identifies likely constraints on the evolution of developmental gene expression. 
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    Free, publicly-accessible full text available June 19, 2026
  2. ; ; ; ; ; ; ; ; ; ; et al (, Nature Materials)
    Free, publicly-accessible full text available December 1, 2025
  3. ; ; ; ; ; ; ; ; ; ; et al (, Developmental Cell)
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  4. ; ; ; ; ; ; ; ; ; ; et al (, Cell)
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